Publications

All Publications in PubMed

Gene Regulation

  • Yang J, Gao C, Chai L, and Ma, Y A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells. PLoS One. 2010 May 21;5(5):e10766. Available from: https://doi.org/10.1371/journal.pone.0010766. PMCID: PMC2874005
  • Trinh BQ, Ummarino S, Zhang Y, Ebralidze AK, Bassal MA, Nguyen TM, Heller G, Coffey R, Tenen DE, van der Kouwe E, Fabiani E, Gurnari C, Wu CS, Angarica VE, Yang H, Chen S, Zhang H, Thurm AR, Marchi F, Levantini E, Staber PB, Zhang P, Voso MT, Pandolfi PP, Kobayashi SS, Chai L, Di Ruscio A, Tenen DG. Myeloid lncRNA LOUP mediates opposing regulatory effects of RUNX1 and RUNX1-ETO in t(8;21) AML. Blood. 2021 Oct 14;138(15):1331-1344. doi: 10.1182/blood.2020007920. PMID: 33971010; PMC8525335
  • Kwon J, Liu YV, Gao C, Bassal MA, Jones AI, Yang J, Chen Z, Li Y, Yang H, Chen L, Di Ruscio A, Tay Y, Chai L, Tenen DG. Pseudogene-mediated DNA demethylation leads to oncogene activation. Sci Adv. 2021 Oct;7(40):eabg1695. doi: 10.1126/sciadv.abg1695. PMID: 34597139.
  • Liu YC, Kwon J, Fabiani E, Xiao Z, Liu YV, Follo MY, Liu J, Huang H, Gao C, Liu J, Falconi G, Valentini L, Gurnari C, Finelli C, Cocco L, Liu JH, Jones AI, Yang J, Yang H, Thoms JAI, Unnikrishnan A, Pimanda JE, Pan R, Bassal MA, Voso MT, Tenen DG, Chai L. Demethylation and Up-Regulation of an Oncogene after Hypomethylating Therapy. N Engl J Med. 2022 May 26;386(21):1998-2010. doi: 10.1056/NEJMoa2119771. PMID: 35613022.
  • Yang J, Gao C, Liu M, Liu YC, Kwon J, Qi J, Tian X, Stein A, Liu YV, Kong NR, Wu Y, Yin S, Xi J, Chen Z, Kumari K, Wong H, Luo H, Silberstein LE, Thoms JAI, Unnikrishnan A, Pimanda JE, Tenen DG, Chai L. Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy. Cancer Res. 2021 Dec 1;81(23):6018-6028. doi: 10.1158/0008-5472.CAN-21-0030. PMID: 34593523; PMC8639708.

 

Stem Cells and Cancer

  • Zhang J, Tam WL, Tong GQ, Wu Q, Chan HY, Soh BS, Lou Y, Yang J, Ma Y, Chai L, Ng HH, Lufkin T, Robson P, Lim B. Sall4 Modulates Embryonic Stem Cell Pluripotency and Early Embryonic Development by the Transcriptional Regulation of Pou5f1. Nat Cell Biol. 2006 Oct;8(10):1114-23. PMID: 16980957.
  • Yang J, Chai L, Fowles TC, Alipio Z, Xu D, Fink LM, Ward DC, Ma Y. Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells. PNAS. 2008 Dec 16;105(50):19756-61. doi: 10.1073/pnas.0809321105. PMCID: PMC2604985.
  • Yang J, Gao C, Chai L, and Ma, Y A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells. PLoS One. 2010 May 21;5(5):e10766. Available from: https://doi.org/10.1371/journal.pone.0010766. PMCID: PMC2874005.
  • Gao C, Kong N, Li A, Tatetsu H, Ueno S, Yang Y, He J, Yang J, Ma, Y, Kao G, Tenen DG, Chai L. SALL4 is a key transcription regulator in normal human hematopoiesis. Transfusion. 2013 May; 53(5):1037-1049.

 

Targeting Transcription Factors in Cancer

  • Ueno S, Lu J, He J, Li A, Zhang X, Ritz J, Silberstein LE, Chai L. Aberrant expression of SALL4 in acute B cell lymphoblastic leukemia: mechanism, function, and implication for a potential novel therapeutic target. Exp Hematol. 2014 Apr;42 PMCID: PMC4135469
  • Jeong H, Cui W, Yang Y, Lu J, He J, Li A, Song D, Guo Y, Liu B, and Chai L. SALL4, a stem cell factor, affects the side population by regulation of the ATP-binding cassette drug transport genes, PLoS One. 2011 Apr 19;6(4):e18372. doi: 10.1371/journal.pone.0018372. PMCID: PMC3079717
  • Li A, Jiao Y, Yong KJ, Wang F, Gao C, Yan B, Srivastava S, Lim GS, Tang P, Yang H, Tenen DG, Chai L. SALL4 is a new target in endometrial cancer. Oncogene. 2013 Dec. doi: 10.1038/onc.2013.529. PMCID: PMC4059794
  • Yang J, Chai L, Fowles T, Alipio Z, Gao C, Fink L, Ma Y. SALL4 is a key regulator of survival and apoptosis in human leukemic cells. Blood. 2008 Aug; 112(3):805-813. PMCID: PMC2481537
  • Yong K, Gao C, Yan B, Yang H, Lim J, Dimitrov T, Kawasaki A, Ong C, Lee S, Ravikumar1 S, Srivastava S, Tian X, Luk J, Dan YY, Salto-Tellez M, Chai L, Tenen DG. Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. N Engl J Med. 2013 Jun; 368(24):2266-2276.
  • Lu J, Jeong H, Kong N, Yang Y, Carroll J, Luo R, Silberstein L, Ma Y and Chai L. Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex, PLoS One. 2009;4(5):e5577. doi: 10.1371/journal.pone.0005577. PMCID: PMC 2679146
  • Gao C, Dimitrov T, Yong KJ, Jeong H, Luo L Tenen DG, and Chai L. A peptide blocking transcription factor SALL4 interaction with an epigenetic complex induces cell death in acute myeloid leukemia, Blood. 2013 Feb 21;121(8):1413-21. doi: 10.1182/blood-2012-04-424275. PMCID: PMC3578956
  • Liu B, Jobichen C, Chia C, Tang J, Chan H, Chung T, Poulsen A, Hung A, Koh-Stenta X, Tan Y, Verma C, Hill J, Chai L, Sivaraman J and Tenen DG, Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide, Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7119-E7128. doi: 10.1073/pnas.1801253115. PMID:29976840.
  • Li A, Yang Y, Gao C, Lu J, Jeong J, Liu B, Tang P, Tenen DG, Chai L. A SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesis. J Clin Invest. 2013 Oct; 123(10):4195-4207. PMCID: PMC3784519
  • Yang J, Chai L, Liu F, Fink L, Lin P, Silberstein L, Amin HM, Ward D, Ma Y. Bmi-1 is a SALL4 target gene in hematopoietic and leukemic stem cells. PNAS. 2007 Jun; 104(25): 10494-10499
  • Yong KJ, Li A, Ou W, Zhao W, Wang F, Tatetsu H, Yan B, Qi L, Fletcher JA, Yang H, Soo R, Tenen DG, and Chai L. Targeting a novel SALL4/CBL-B pathway in lung cancer, Oncotarget, 2016 Sep 26. doi: 10.18632/oncotarget.12251. PMCID: PMC5342750
  • Tan JL, Li F, Yeo JZ, Yong KJ, Bassal MA, Ng GH, Lee MY, Leong CY, Tan HK, Wu CS, Liu BH, Chan TH, Tan ZH, Chan YS, Wang S, Lim ZH, Toh TB, Hooi L, Low KN, Ma S, Kong NR, Stein AJ, Wu Y, Thangavelu MT, Suzuki A, Periyasamy G, Asara JM, Dan YY, Bonney GK, Chow EK, Lu GD, Ng HH, Kanagasundaram Y, Ng SB, Tam WL, Tenen DG, and Chai L. New High-throughput Screen Identifies Compounds That Reduce Viability Specifically In Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation. Gastroenterology. 2019 Aug 22. pii: S0016-5085(19)41242-0. Available from: https://doi.org/10.1053/j.gastro.2019.08.022 PMCID: PMC7309153
  • Kong, NR, Bassal, MA, Tan, HK, Kurland, JV, Yong, KJ, Young, JJ, Yang, Y, Li, F, Lee, JD, Liu, Y, Wu, CS, Stein, A, Luo, HR, Silberstein, LE, Bulyk, ML, Tenen, DG, Chai L. Zinc Finger Protein SALL4 Functions through an AT Rich Motif to Regulate Gene Expression. Cell Reports, 2021 Jan 5;34(1):108574. Available from: https://doi.org/10.1016/j.celrep.2020.108574 PMID: 33406418.

 

Normal Hematopoiesis in Transfusion Medicine

  • Tatetsu H, Armant M, Wang F, Gao C, Ueno S, Tian X, Federation A, Qi J, Bradner J, Tenen DG, Chai L. Maintenance and enhancement of human peripheral blood mobilized stem/progenitor cell engraftment after ex vivo culture via an HDACi/SALL4 axis (3465). Exp Hematol. 2019 Jul;75:53-63.e11. doi: 10.1016/j.exphem.2019.06.473. PMID: 31260717; PMC6719293.
  • Gao C, Kong N, Li A, Tatetsu H, Ueno S, Yang Y, He J, Yang J, Ma, Y, Kao G, Tenen DG, Chai L. SALL4 is a key transcription regulator in normal human hematopoiesis. Transfusion. 2013 May; 53(5):1037-1049.
  • Fan Y, Teng Y, Loison F, Pang A, Kasorn A, Shao X, Zhang C, Ren Q, Yu H, Zheng Y, Cancelas JA, Manis J, Chai L, Park SY, Zhao L, Xu Y, Feng S, Silberstein LE, Ma F, Luo HR. Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion. Sci Transl Med. 2021 Jul 28;13(604):eabb1069. doi: 10.1126/scitranslmed.abb1069. PMID: 34321317.
  • Lu J, Sun Y, Nombela-Arrieta C, Du KP, Park SY, Chai L, Walkley C, Luo HR, Silberstein LE. Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion. Exp Hematol. 2012 Apr;40(4):307-17.e3. doi: 10.1016/j.exphem.2011.11.010. PMID: 22155722; PMC3307834.
  • Liang OD, Lu J, Nombela-Arrieta C, Zhong J, Zhao L, Pivarnik G, Mondal S, Chai L, Silberstein LE, Luo HR. Deficiency of lipid phosphatase SHIP enables long-term reconstitution of hematopoietic inductive bone marrow microenvironment. Dev Cell. 2013 May 28;25(4):333-49. doi: 10.1016/j.devcel.2013.04.016. PMID: 23725762; PMC3673722.
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